Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Aggregated recombinant human alpha-synuclein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.5?- 5.0??g/mL?for chromogenic staining and 0.1?- 2.0??g/mL?for fluorescent staining is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2810765 (BioLegend Cat. No. 865001) AB_2810766 (BioLegend Cat. No. 865002)
Antigen Details
- Structure
- Human α-synuclein is a 140 amino acid protein with a molecular mass of 14 kD.
- Distribution
-
Tissue distribution: Primarily nervous system, but lower expression in other tissues such as blood and skin.
Cellular distribution: Cytoskeleton, cytosol, lysosome, mitochondria, nucleus, plasma membrane, and extracellular. - Function
- α-synuclein plays several roles in synaptic activity such as synaptic vesicle trafficking and neurotransmitter release. It is also involved in the regulation of gene expression.
- Interaction
- Interacts with various proteins, such as UCHL1, phospholipase D, histones and SNARE components.
- Cell Type
- Neurons
- Biology Area
- Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Synaptic Biology
- Molecular Family
- α-Synuclein, Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis
- Antigen References
-
- Mor DE, et al. 2016. Neurobiol. Dis. 88:66.
- Jucker M, Walker LC. 2013. Nature. 501(7465):45.
- Bartels T, et al. 2011. Nature. 477(7362):107.
- Devine MJ, et al. 2011. Mov. Disord. 26:2160.
- Gene ID
- 6622 View all products for this Gene ID
- UniProt
- View information about alpha-Synuclein on UniProt.org
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