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APC anti-human CD197 (CCR7) Antibody

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Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
CCR7-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Red Laser (633 nm)
Product Citations
  1. Li M, et al. 2021. J Clin Invest. 131:. PubMed
  2. Andonian BJ, et al. 2022. Sci Rep. 12:7450. PubMed
  3. Shen Y, et al. 2021. Cell Stress Chaperones. 26:937. PubMed
  4. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  5. Chiu YL, et al. 2018. Immun Ageing. 15:27. PubMed
  6. Blengio F, et al. 2013. Immunobiology. 218:76. PubMed
  7. Liu C, et al. 2021. Cell Res. 31:1106. PubMed
  8. Guo J, et al. 2022. Front Cell Dev Biol. 9:775599. PubMed
  9. Fajgenbaum DC, et al. 2019. J Clin Invest. 130:4451. PubMed
  10. Jo T, et al. 2022. Cancer Immunol Immunother. Online ahead of print. PubMed
  11. Miao L, et al. 2021. Clin Transl Med. 11:e395. PubMed
  12. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  13. Luo Y, et al. 2021. Nat Commun. 12:3913. PubMed
  14. Cho JH, et al. 2021. Nat Commun. 12:792. PubMed
  15. Dai X, et al. 2021. Bioact Mater. 1.659027778. PubMed
  16. Soriano-Sarabia N, et al. 2014. J Virol. 88:14070. PubMed
  17. Yin S, et al. 2015. Sci Rep. 5: 14432. PubMed
  18. Bradley T et al. 2018. Cell reports. 25(1):107-117 . PubMed
  19. Koh WH, et al. 2020. STAR Protoc. 1:100203. PubMed
  20. Ronaghan NJ, et al. 2022. PLoS One. 17:e0276013. PubMed
  21. Mysore V, et al. 2021. Med (N Y). 2:1050. PubMed
RRID
AB_10915474 (BioLegend Cat. No. 353213) AB_10917387 (BioLegend Cat. No. 353214)

Antigen Details

Structure
Chemokine receptor, G protein-coupled receptors (GPCR), seven transmembrane receptor.
Distribution

T cells, B cells, NK, dendritic cells.

Function
The chemokine receptor CCR7 plays a pivotal role in the homing of na?ve T cells and regulatory T cells to secondary lymphoid organs, and the migration of dendritic cells into afferent lymphatic vessels.
Ligand/Receptor
CCL19 and CCL21.
Cell Type
B cells, Dendritic cells, NK cells, T cells
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Yanagihara S,　et al.　1998.　J. Immunol.　161:3096.
2. Charo IF,　et al.　2006.　N. Engl. J. Med.　354:610.
3. Reif K,　et al.　2002.　Nature　416:94.
4. Nakata B,　et al.　2008.　Oncology　74:69.
5.　Brodie T.　et al. 2013.　Cytometry A.　6: 530-2.　PubMed
6. Graves A.J. et al. 2014. Cytometry A. 7: 576–9　PubMed
7. Moncunill G. et al. 2014. Cytometry A. 12: 995-8　PubMed

Gene ID
1236 View all products for this Gene ID
UniProt
View information about CD197 on UniProt.org
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