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PE anti-human CD197 (CCR7) Antibody

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Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
CCR7-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Aschmoneit N, et al. 2021. J Immunother Cancer. 9:. PubMed
  2. Rendeiro AF, et al. 2020. Nat Commun. 11:577. PubMed
  3. Li M, et al. 2022. Sci Rep. 12:378. PubMed
  4. Zeng W, et al. 2017. Front Immunol. 0.806944444. PubMed
  5. Zhou R, et al. 2020. Immunity. S1074-7613(20)30333-2.. PubMed
  6. Acharya N, et al. 2020. Immunity. 53(3):658-671.e6. PubMed
  7. Kubo M, et al. 2018. Oncol Rep. 39:417. PubMed
  8. Kramer KJ, et al. 2022. Nat Commun. 13:3466. PubMed
  9. Xiong X, et al. 2021. Liver Int. 41:1033. PubMed
  10. Cappellano G, et al. 2018. PLoS One. 13:e0192108. PubMed
  11. Kang L, et al. 2020. Exp Hematol Oncol. 9:11. PubMed
  12. Tatovic D, et al. 2015. J Immunol. 195: 386 - 392. PubMed
  13. Zhang X, et al. 2021. Nat Commun. 12:5291. PubMed
  14. Gullà A, et al. 2021. Cancer Discov. . PubMed
  15. Aschmoneit N, et al. 2022. Oncoimmunology. 11:2028961. PubMed
  16. Balan I, et al. 2022. Front Immunol. 13:940095. PubMed
  17. Kuo HH, et al. 2018. Immunity. 48:1183. PubMed
  18. Alhaj Hussen K, et al. 2017. Immunity. 47:680. PubMed
  19. Ahmad S,et al. 2017. Prog Neuropsychopharmacol Biol Psychiatry. . 10.1016/j.pnpbp.2017.10.001. PubMed
  20. Wu J et al. 2019. Immunity. 50(5):1218-1231 . PubMed
  21. Magri G et al. 2017. Immunity. 47(1):118-134 . PubMed
  22. Aschmoneit N, et al. 2021. Sci Rep. 11:13880. PubMed
  23. Vadrevu KM, et al. 2022. Sci Rep. 12:12038. PubMed
  24. Borowicz S, et al. 2021. PLOS ONE. 16(6):e0252197. PubMed
  25. Usmani SM et al. 2019. Cell host & microbe. 25(1):73-86 . PubMed
  26. Christiansen M, et al. 2020. Front Immunol. 10:3022. PubMed
  27. Tavira B, et al. 2018. J Diabetes Res. 2018:9391845. PubMed
  28. Audigé A, et al. 2017. BMC Immunology. 10.1186/s12865-017-0209-9. PubMed
  29. Ramos MIP, et al. 2021. Elife. 10:. PubMed
  30. Hirschberger S, et al. 2021. EMBO Mol Med. 13:e14323. PubMed
  31. Collins PL et al. 2018. Cell. 176(1-2):348-360 . PubMed
  32. Chen Y, et al. 2020. Cell. 1496:183. PubMed
  33. Montel‐Hagen A et al. 2019. Cell stem cell. 24(3):376-389 . PubMed
  34. Gullà A, et al. 2021. Cancer Discov. 2:468. PubMed
  35. Chen R, et al. 2021. Front Oncol. 11:743050. PubMed
  36. Gamradt S, et al. 2021. iScience. 24:103312. PubMed
RRID
AB_10916391 (BioLegend Cat. No. 353203) AB_10913813 (BioLegend Cat. No. 353204)

Antigen Details

Structure
Chemokine receptor, G protein-coupled receptors (GPCR), seven transmembrane receptor.
Distribution

T cells, B cells, NK, dendritic cells.

Function
The chemokine receptor CCR7 plays a pivotal role in the homing of na?ve T cells and regulatory T cells to secondary lymphoid organs, and the migration of dendritic cells into afferent lymphatic vessels.
Ligand/Receptor
CCL19 and CCL21.
Cell Type
B cells, Dendritic cells, NK cells, T cells
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Yanagihara S, et al. 1998. J. Immunol. 161:3096.
2. Charo IF, et al. 2006. N. Engl. J. Med. 354:610.
3. Reif K, et al. 2002. Nature 416:94.
4. Nakata B, et al. 2008. Oncology 74:69.
5. Brodie T. et al. 2013. Cytometry A. 6: 530-2. PubMed
6. Graves A.J. et al. 2014. Cytometry A. 7: 576–9 PubMed
7. Moncunill G. et al. 2014. Cytometry A. 12: 995-8 PubMed

Gene ID
1236 View all products for this Gene ID
UniProt
View information about CD197 on UniProt.org
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