Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Human CCR5 transfectants
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE/Cyanine5 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?L per million cells in 100 ?L staining volume or 5 ?L per 100 ?L of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
- AB_2910404 (BioLegend Cat. No. 359143) AB_2910404 (BioLegend Cat. No. 359144)
Antigen Details
- Structure
- G-coupled receptor family 1, membrane protein, 45 kD
- Distribution
-
Subset of T cells, monocytes
- Function
- Binds C-C chemokines and transduces an intracellular signal thought to result in proliferation and differentiation, acts as a co-receptor with CD4 for HIV-1
- Ligand/Receptor
- MIP-1α, MIP-1β, RANTES
- Cell Type
- Monocytes, T cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
-
- Samson M, et al. 1996. Biochemistry. 35:3362-7.
- Raport CJ, et al. 1996. J Biol Chem. 271:17161-6.
- Combadiere C, et al. 1996. J Leukoc Biol. 60:147-52.
- Deng H, et al. 1996. Nature. 381:661-6.
- Lai J, et al. 2003. CVI. 10:1123-8.
- Ma?es S, et al. 2003. J Exp Med. 198:1381-9.
- Vaday GG, et al. 2006. Prostate 66:124-34.
- Gene ID
- 1234 View all products for this Gene ID
- UniProt
- View information about CD195 on UniProt.org
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