Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human SCF
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2564302 (BioLegend Cat. No. 662502)
Antigen Details
- Structure
- Homodimer (non-covalently linked).
- Distribution
- Cytoplasm and cytoskeleton.
- Function
- Stem Cell Factor (SCF) plays a role in the regulation of cell proliferation, melanocyte differentiation, innate immune response, hematopoiesis, stem cell maintenance, mast cell development, migration, and function. Binding of SCF to c-Kit leads to the activation of PI3 kinase, Src kinase, and several signaling pathways including JAK/STAT pathway (activation of STATs) and Ras/Erk pathway (transmit signals through adaptor protein Grb2).
- Interaction
- Mast cells, natural killer cells, dendritic cells, eosinophils, epithelial cells, endothelial cells, melanocytes, germ cells, cholangiocytes, platelets, myeloid leukaemia cells, and intestinal cells of Cajal.
- Ligand/Receptor
- c-kit (CD117)
- Biology Area
- Angiogenesis, Cell Biology, Immunology, Signal Transduction, Stem Cells
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
1. Lu HS, et al. 1996. J. Biol. Chem. 271:11309.
2. Heissig B, et al. 2002. Cell 109:625.
3. Ronnstrand L. 2004. Cell Mol. Life Sci. 61:19-20.
4. Jin DK, et al. 2006. Nat. Med. 12:557.
5. Krishnamoorthy N, et al. 2008. Nat. Med. 14:565.
6. Ray P, et al. 2010. Ann. N. Y. Acad. Sci. 1183:104. - Gene ID
- 4254 View all products for this Gene ID
- UniProt
- View information about SCF on UniProt.org
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