Product Details
- Verified Reactivity
- Mouse, Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse LIF produced in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Verified - Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 ?g per mL. For immunocytochemistry, a concentration range of 2.0 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2565278 (BioLegend Cat. No. 674702)
Antigen Details
- Structure
- 202 amino acids with a predicted molecular weight of approximately 22 kD.
- Distribution
-
Expressed in the trophectoderm of the developing embryo, activated CD4+ T cells.
- Function
- Inhibits embryonic stem cell differentation and induces the terminal differentiation of myeloid leukemia cells. LIF is upregulated by TNF-α and IL-17. LIF is downregulated by IL-4 and IL-13 in fibroblasts.
- Interaction
- Embryonic stem cells.
- Ligand/Receptor
- LIF receptor complex (gp190 and gp130).
- Cell Type
- T cells, Tregs
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- Cytokines/Chemokines, Growth Factors
- Antigen References
-
1. Moreau JF, et al. 1988. Nature 336:690.
2. Tomida M, et al. FEBS Lett. 334:193.
3. Metcalfe SM. 2011. Genes Immun. 12:157.
4. Voyle RB, et al. 1999. Exp. Cell Res. 249:199.
5. Slaets H, et al. 2010. Trends Mol. Med. 16:493.
6. Souza PP, et al. 2012. Mol. Immunol. 49:601 - Gene ID
- 3976 View all products for this Gene ID
- UniProt
- View information about LIF on UniProt.org
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