Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human TIMP-1.
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- Affinity purified.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2565609 (BioLegend Cat. No. 676002)
Antigen Details
- Structure
- Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD.
- Distribution
-
Widely expressed in mammalian tissues, notably in reproductive organs.
- Function
- TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes.
- Interaction
- MMP-1, MMP-3, MMP-9.
- Ligand/Receptor
- CD63.
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
1. Brew K and Nagase H. 2010. Biochim. Biophys. Acta. 1803:55.
2. Murphy G. 2011. Genome Biol. 12:233.
3. Bourboulia D and Stetler-Stevenson WG. 2010. Semin. Cancer Biol. 20:161.
4. Kim YS, et al. 2012. BMB Rep. 45:623.
5. Ries C. 2014. Cell Mol. Life Sci. 71:659. - Gene ID
- 30949 View all products for this Gene ID
- UniProt
- View information about TIMP-1 on UniProt.org
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