Product Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human MMP-1.
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- Affinity purified.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 1.25 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2565606 (BioLegend Cat. No. 675702)
Antigen Details
- Structure
- Monomer, belongs to the peptidase M10A family. 469 amino acids, predicted molecular weight of 54 kD.
- Distribution
- Extracellular. MMP-1 is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes, and macrophages.
- Function
- MMP1 cleaves collagen of types I, II, III, VII and X. MMP-1 is thought to play an important role in the pathogenesis of rheumatoid and osteo-arthritis as mediators of cartilage and bone destruction. It is also involved in angiogenesis, tissue remodeling and cancer metastasis. MMP-1 regulates chemokine activity. MMP1 is inhibited by TIMPs, ?±2-macroglobulin (inhibitor of MMPs in bodily fluids). TNF-alpha; down-regulates TIMPs and enhances the expression of MMPs.
- Interaction
- MCP1, MCP3, MCP4, TIMP-1, MMP7, Collagen type II α1, IBP-3, Integrin α2, CD44, CD147, Brevican, Chymase 1, Aggrecan 1.
- Ligand/Receptor
- TIMPs.
- Biology Area
- Angiogenesis, Cell Adhesion, Cell Biology, Neuroinflammation, Neuroscience
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
1. Nagase H and Woessner JF Jr. 1999. J. Biol. Chem. 274:21491.
2. Boire A, et al. 2005. Cell 120:303.
3. Kader AK, et al. 2007. Clin. Cancer Res. 13:2614.
4. Gill SE and Parks WC. 2008. Int. J. Biochem. Cell Biol. 40:1334.
5. Mazor R, et al. 2013. J. Biol. Chem. 288:598.
6. Sommer K, et al. 2013. PLos One 8:e73992. - Gene ID
- 1029 View all products for this Gene ID
- UniProt
- View information about MMP-1 on UniProt.org
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