Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human MMP-3, amino acids Tyr18 -Cys477, was expressed with N-terminal His9-SGGGSGGGIEGR tag in 293E cells.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
- AB_2566077 (BioLegend Cat. No. 679202)
Antigen Details
- Structure
- Belongs to the peptidase M10A family. Monomer. Contains 4 hemopexin-like domains with an approximate predicted molecular weight of 54 kD. Mature form of MMP3 upon activation by p-aminophenylmercuric acetate (APMA), has predicted molecular weight of 45 kD.
- Distribution
- Extracellular. MMP3 is expressed by fibroblasts, chondrocytes, osteoblasts, endothelial cells, smooth muscle cells, and macrophages.
- Function
- MMP3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V, collagens III, IV, X, and IX, and cartilage proteoglycans. It activates procollagenases. MMP3 is thought to play a prominent role in the pathogenesis of rheumatoid arthritis.
- Interaction
- Fibronectin, laminin, collagens III, IV, IX, and X, cartilage proteoglycans, decorin, osteopontin, and IBP-3.
- Ligand/Receptor
- Tissue inhibitors of metalloproteinases (TIMPs).
- Biology Area
- Angiogenesis, Cell Adhesion, Cell Biology, Neuroinflammation, Neuroscience
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
1. Matrisian LM. 1990. Trends Genet. 4:121.
2. Nagase H and Woessner JF Jr. 1999. J. Biol. Chem. 274:21491.
3. Humphries SE, et al. 1998. Atherosclerosis 139:49.
4. Kader AK, et al. 2007. Clin. Cancer Res. 13:2614.
5. Gill SE and Parks WC. 2008. Int. J. Biochem. Cell Biol. 40:1334.
6. Mazor R, et al. 2013. J. Biol. Chem. 288:598.
7. Herath TD, et al. 2013. BMC Microbiol. 13:73. - Gene ID
- 4314 View all products for this Gene ID
- UniProt
- View information about MMP-3 on UniProt.org
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