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產品編號	bs-1074R
英文名稱	Rabbit　Anti-Nrf2　antibody
中文名稱	核因子2相關因子2抗體
別　　　　名	Nuclear factor-E2 related factor2; Nrf-2; HEBP1; NF E2 related factor 2; NFE2 related factor 2; NFE2L2; Nrf 2; Nuclear factor erythroid 2 related factor 2; Nuclear factor erythroid derived 2 like 2; NF2L2_HUMAN.
	Specific References　　(123)　　　　　\|　　　　　bs-1074R has been referenced in 123 publications. [IF=10.183]　Jae Yeon Kim. et al. Increased PRL-1 in bone marrow-derived mesenchymal stem cells triggers anaerobic metabolism via mitochondria in a cholestatic rat model. MOL THER-NUCL ACIDS. 2023 Feb 04　　WB　;　　Rat.　　 PubMed:36865088 [IF=8.724]　Jianmei Li. et al. Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS. Bioact Mater. 2021 Nov;6:3839　　IF　;　　Rat.　　 PubMed:33898880 [IF=8.44]　Li Xiangdong. et al. Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3. J TRANSL MED. 2023 Dec;21(1):1-19　　WB　;　　Mouse.　　 PubMed:36788538 [IF=8.355]　Shi S et al. Homologous-targeting biomimetic nanoparticles for photothermal therapy and Nrf2-siRNA amplified photodynamic therapy against oral tongue squamous cell carcinoma. Chemical Engineering Journal, 2020, 124268.　　WB　;　　Human.　　 PubMed:doi:10.1016/j.cej.2020.124268 [IF=7.675]　Hee Jung Park. et al. Phosphatase of Regenerating Liver-1 (PRL-1)-Overexpressing Placenta-Derived Mesenchymal Stem Cells Enhance Antioxidant Effects via Peroxiredoxin 3 in TAA-Injured Rat Livers. ANTIOXIDANTS-BASEL. 2023 Jan;12(1):46　　WB　;　　Rat.　　 PubMed:36670907 [IF=7.675]　Shuang Wang. et al. Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling. ANTIOXIDANTS-BASEL. 2022 Dec;11(12):2443　　IF　;　　Rat.　　 PubMed:36552651 [IF=7.675]　Xiaoxiao Zou. et al. Milk Fat Globule Membrane Relieves Fatigue via Regulation of Oxidative Stress and Gut Microbiota in BALB/c Mice. ANTIOXIDANTS-BASEL. 2023 Mar;12(3):712　　WB　;　　Mouse.　　 PubMed:36978962 [IF=7.129]　Yuan-yuan Wei. et al. Acute liver injury induced by carbon tetrachloride reversal by Gandankang aqueous extracts through nuclear factor erythroid 2-related factor 2 signaling pathway. ECOTOX ENVIRON SAFE. 2023 Feb;251:114527　　IHC　;　　Mouse.　　 PubMed:36628874 [IF=7.129]　Rui Sang. et al. Taraxasterol alleviates aflatoxin B1-induced liver damage in broiler chickens via regulation of oxidative stress, apoptosis and autophagy. ECOTOX ENVIRON SAFE. 2023 Feb;251:114546　　WB　;　　Chicken.　　 PubMed:36646010 [IF=7.129]　Jie Luo. et al. Copper nanoparticles lead to reproductive dysfunction by affecting key enzymes of ovarian hormone synthesis and metabolism in female rats. ECOTOX ENVIRON SAFE. 2023 Apr;254:114704　　WB　;　　Rat.　　 PubMed:36898311 [IF=7.086]　Xue Yang. et al. The heart as a target for deltamethrin toxicity: Inhibition of Nrf2/HO-1 pathway induces oxidative stress and results in inflammation and apoptosis. Chemosphere. 2022 Aug;300:134479　　WB　;　　Japanese Quails.　　 PubMed:35367492 [IF=6.953]　Jinshan Wu. et al. Protection by Hosta ventricosa polysaccharides against oxidative damage induced by t-BHP in HepG2 cells via the JNK/Nrf2 pathway. Int J Biol Macromol. 2022 May;208:453　　WB　;　　Human.　　 PubMed:35339497 [IF=6.832]　Tao Cai. et al. Long noncoding RNA BBOX1-AS1 promotes the progression of gastric cancer by regulating the miR-361-3p/Mucin 13 signaling axis. BIOENGINEERED. 2022 Jun 05　　WB　;　　Human.　　 PubMed:10.1080/21655979.2022.2072629 [IF=6.792]　Jiayi Li. et al. Toxicological effects of deltamethrin on quail cerebrum: Weakened antioxidant defense and enhanced apoptosis. Environ Pollut. 2021 Oct;286:117319　　WB　;　　Quail.　　 PubMed:33990053 [IF=6.543]　Zhong Li. et al. The TBX1/miR-193a-3p/TGF-β2 Axis Mediates CHD by Promoting Ferroptosis. Oxid Med Cell Longev. 2022;2022:5130546　　WB　;　　Human.　　 PubMed:35035663 [IF=6.543]　Deng Liangjun. et al. The Attenuation of Chronic Ulcerative Colitis by (R)-salbutamol in Repeated DSS-Induced Mice. Oxid Med Cell Longev. 2022;2022:9318721　　WB,IF　;　　Mouse.　　 PubMed:35178163 [IF=6.543]　Wang Da-Peng. et al. URB597 and Andrographolide Improve Brain Microvascular Endothelial Cell Permeability and Apoptosis by Reducing Oxidative Stress and Inflammation Associated with Activation of Nrf2 Signaling in Oxygen-Glucose Deprivation. OXID MED CELL LONGEV. 2022;2022:4139330　　WB　;　　Mouse.　　 PubMed:35602108 [IF=6.543]　Yuan Jiyan. et al. Vitamin B12 Attenuates Acute Pancreatitis by Suppressing Oxidative Stress and Improving Mitochondria Dysfunction via CBS/SIRT1 Pathway. Oxid Med Cell Longev. 2021;2021:7936316　　WB　;　　Mouse.　　 PubMed:34925701 [IF=6.344]　Xin, Liangjing. et al. Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system. INT J ORAL SCI. 2022 May;14(1):1-12　　IHC　;　　Mouse.　　 PubMed:35637195 [IF=6.291]　Xiao Wang. et al. Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis. Ecotox Environ Safe. 2022 Mar;233:113339　　WB　;　　Chicken.　　 PubMed:35219255 [IF=6.291]　Xi Su. et al. Chronic developmental exposure to low-dose ([C8mim][PF6]) induces neurotoxicity and behavioural abnormalities in rats. Ecotox Environ Safe. 2021 Dec;225:112806　　WB　;　　Rat.　　 PubMed:34555716 [IF=6.291]　Shaofeng Wu. et al. The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks. Ecotox Environ Safe. 2021 Dec;228:112965　　WB　;　　Duck.　　 PubMed:34775344 [IF=6.208]　Shuang Wang. et al. Paricalcitol Ameliorates Acute Kidney Injury in Mice by Suppressing Oxidative Stress and Inflammation via Nrf2/HO-1 Signaling. INT J MOL SCI. 2023 Jan;24(2):969　　IF　;　　Mouse.　　 PubMed:36674485 [IF=6.208]　Yuya Otaka. et al. 5-ALA/SFC Ameliorates Endotoxin-Induced Ocular Inflammation in Rats by Inhibiting the NF-κB Signaling Pathway and Activating the HO-1/Nrf2 Signaling Pathway. INT J MOL SCI. 2023 Jan;24(10):8653　　IHC　;　　Rat.　　 PubMed:37239995 [IF=6.117]　Yuanyuan Xing. et al. Artemisia ordosica polysaccharide ameliorated LPS-induced growth inhibition and intestinal injury in broilers through enhancing immune-regulation and antioxidant capacity. J NUTR BIOCHEM. 2023 Feb;:109284　　WB　;　　Chicken.　　 PubMed:36828238 [IF=5.81]　Xinyue Chang. et al. The Protective Effect of Trichilia catigua A. Juss. on DEHP-Induced Reproductive System Damage in Male Mice. Front Pharmacol. 2022; 13: 832789　　IHC　;　　Mouse.　　 PubMed:35185586 [IF=5.589]　Lv Y et al. Imidacloprid-induced liver fibrosis in quails via activation of the TGF-β1/Smad pathway. Sci Total Environ. 2019 Dec 6;705:135915.　　WB　;　　Quail.　　 PubMed:31835194 [IF=5.552]　Huang, Jianjia. et al. Lycium barbarum polysaccharides ameliorate canine acute liver injury by reducing oxidative stress, protecting mitochondrial function, and regulating metabolic pathways. J ZHEJIANG UNIV-SC B. 2023 Feb;24(2):157-171　　WB　;　　Dog.　　 PubMed:36751701 [IF=5.34]　Qingwen Hu. et al. β-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats. PHYTOMEDICINE. 2022 Jul;102:154112　　WB　;　　Rat.　　 PubMed:35550220 [IF=5.27]　Lee, Bao-Hong, et al. "Dimerumic acid attenuates receptor for advanced glycation endproduct (RAGE) signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promoted methylglyoxal metabolism into D-lactate acid" Free Radical Biology and Medicine　　WB　;　　Human.　　 PubMed:23434766
研究領域	腫瘤　　免疫學　　染色質和核信號　　合成與降解
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Rat,Mouse,Human (predicted: Rabbit,Horse,Cow,Pig,Dog,Chicken)
產品應用	WB=1:100-1000, IHC-P=1:100-1000, IHC-F=1:100-1000, ICC=1:100, IF=1:100-1000, ELISA=1:1000-5000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理論分子量	68kDa
細胞定位	細胞核　細胞漿
性　　　　狀	Liquid
濃　　　　度	1mg/ml
免　疫　原	KLH conjugated synthetic peptide derived from human Nrf2:　401-500/605
亞　　　　型	IgG
純化方法	affinity purified by Protein A
緩　沖　液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
產品介紹	Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Function: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Subunit: Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1. Subcellular Location: Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents. Tissue Specificity: Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle. Post-translational modifications: Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus. Similarity: Belongs to the bZIP family. CNC subfamily. Contains 1 bZIP domain. SWISS: Q16236 Gene ID: 4780 Database links: Entrez Gene: 4780　Human Omim: 600492　Human SwissProt: Q16236　Human 轉錄調節(jié)因子（Transcriptin Regulators）核細胞系因子2相關因子Nrf2，是一種對氧化還原反應敏感的轉錄因子，可以通過正向促進基因的表達，來轉錄翻譯產生一些抗氧化物，行使著異化解毒的酶類和藥物的高效外排泵作用。有學者認為：核因子2相關因子2蛋白在保護細胞免受環(huán)境毒性物質影響方面發(fā)揮著極其重要的作用，它指導某些基因促進細胞的防御工事，同時也刺激某些重要解毒酶對毒性物質，如黃曲霉素的解毒和排毒作用。
產品圖片	Sample: Lane 1: Kidney (Mouse) Lysate at 40 ug Lane 2: Liver (Mouse) Lysate at 40 ug Lane 3: Liver ((Rat) Lysate at 40 ug Lane 4: SiHa (Human) Cell Lysate at 30 ug Lane 5: HepG2 (Human) Cell Lysate at 30 ug Primary: Anti-Nrf2 (bs-1074R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 110’68 kD Observed band size: 110 kD Paraformaldehyde-fixed, paraffin embedded (rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Nrf2) Polyclonal Antibody, Unconjugated (bs-1074R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Nrf2) Polyclonal Antibody, Unconjugated (bs-1074R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Nrf2) Polyclonal Antibody, Unconjugated (bs-1074R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Nrf2) Polyclonal Antibody, Unconjugated (bs-1074R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining. Tissue/cell: HepG2 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (Nrf2)) polyclonal Antibody, Unconjugated (bs-1074R) 1:100, 90 minutes at 37°C; followed by a FITC conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.