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產(chǎn)品編號	bs-0828R
英文名稱	Rabbit　Anti-PAR1　antibody
中文名稱	蛋白酶激活受體-1抗體
別　　　　名	SAR; PAR-1; PAR 1; BXR; CF2R; F2R; HTR; TR; Proteinase-activated receptor 1 precursor; Proteinase activated receptor 1; Thrombin receptor; Coagulation factor II receptor; Prader-Willi/Angelman region-1; Coagulation factor II (thrombin) receptor; PAR1_HUMAN;
	Specific References　　(12)　　　　　\|　　　　　bs-0828R has been referenced in 12 publications. [IF=4.57]　Daisuke Noguchi. et al. The impact of dabigatran treatment on sinusoidal protection against hepatic ischemia‐reperfusion injury in mice. 2020 Oct 27　　WB　;　　Mouse.　　 PubMed:33108682 [IF=3.53]　Acton, David, and Gareth B. Miles. "Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine." PLOS ONE 10.8 (2015): e0134488.　　IHC-P　;　　Mouse.　　 PubMed:26252389 [IF=3.294]　Posthuma JJ et al. Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes. (2018) J Vasc Surg.　　IHC　;　　Human.　　 PubMed:30314721 [IF=3.161]　Shavit Stein E et al. Thrombin Inhibition Reduces the Expression of Brain Inflammation Markers upon Systemic LPS Treatment.Neural Plast. 2018 Jun 19;2018:7692182.　　WB　;　　Mouse.　　 PubMed:30018633 [IF=3.01]　Liu, Rui, et al. "Identification of FLOT2 as a novel target for microRNA-34a in melanoma." Journal of Cancer Research and Clinical Oncology (2014): 1-14.　　WB　;　　Human.　　 PubMed:25403318 [IF=2.81]　Shimon et al. Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus. (2017) PLoS.One. 12:e0188524　　WB　;　　Mouse.　　 PubMed:29182653 [IF=2.8]　Shimon, Marina Ben, et al. "Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus." PloS one 12.11 (2017): e0188524.　　WB　;　　Mouse.　　 PubMed:29182653 [IF=2.454]　Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status EpilepticusV Golderman　　WB　;　　Mouse.　　 PubMed:30515700 [IF=2.31]　Fan, Hai-Xia, et al. "Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers." OncoTargets and therapy 8 (2015): 1619.　　IHC-P　;　　Human.　　 PubMed:26170698 [IF=2.07]　Chao G et al. Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activityBiomarkers.2021 Feb;26(1):38-44.　　IHC　;　　Rat.　　 PubMed:33176506 [IF=1.872]　Noguchi D et al. Antiapoptotic Effect by PAR-1 Antagonist Protects Mouse Liver Against Ischemia-Reperfusion Injury. J Surg Res. 2019 Oct 22. pii: S0022-4804(19)30689-4.　　WB　;　　Mouse&Human.　　 PubMed:31653415 [IF=1.54]　Akaishi T et al. The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways. Biol Pharm Bull. 2020;43(1):138-144.　　WB　;　　Rat.　　 PubMed:31902919
研究領(lǐng)域	腫瘤　　細胞生物　　信號轉(zhuǎn)導　　激酶和磷酸酶　　細胞膜受體
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human,Mouse,Rat
產(chǎn)品應用	WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理論分子量	42kDa
細胞定位	細胞膜
性　　　　狀	Liquid
濃　　　　度	1mg/ml
免　疫　原	KLH conjugated synthetic peptide derived from human PAR1:　251-350/425
亞　　　　型	IgG
純化方法	affinity purified by Protein A
緩　沖　液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事項	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
產(chǎn)品介紹	Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008] Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Platelets and vascular endothelial cells. Post-translational modifications: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P25116 Gene ID: 2149 Database links: Entrez Gene: 2149 Human Omim: 187930 Human SwissProt: P56488 Baboon SwissProt: P25116 Human Unigene: 482562 Human PAR蛋白全稱為蛋白酶體活化受體(Protease-activated receptors)，又稱：凝血酶受體(Thrombin Receptor)是獨立家族的G蛋白偶聯(lián)受體，研究認為與炎癥，實體腫瘤等密切相關(guān)。 PAR1蛋白是乳腺癌細胞侵潤和遷移的必需因子，它是作為基質(zhì)金屬蛋白酶體1（MMP-1）的受體關(guān)鍵性作用，這一研究結(jié)果為研制新的抗癌藥物提供新的靶點。
產(chǎn)品圖片	Sample: K562(Human) Cell Lysate at 30 ug Primary: Anti-PAR1 (bs-0828R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 42 kD Sample: Brain (Rat) Lysate at 30 ug Liver (Mouse) Lysate at 30 ug Primary: Anti- PAR-1 (bs-0828R) at 1/300 dilution Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 3000 dilution; Predicted band size : 42kD Observed band size : 44kD Sample: Lane 1: U2os (Human) Cell Lysate at 30 ug Lane 2: U251 (Human) Cell Lysate at 30 ug Lane 3: SH-SY5Y (Human) Cell Lysate at 30 ug Lane 4: K562 (Human) Cell Lysate at 30 ug Lane 5: A431 (Human) Cell Lysate at 30 ug Primary: Anti-Thrombin receptor (bs-0828R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kD Observed band size: 62 kD Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Thrombin receptor PAR1) Polyclonal Antibody, Unconjugated (bs-0828R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Thrombin receptor/ PAR1) Polyclonal Antibody, Unconjugated (bs-0828R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: human mammary cancer; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PAR1 Polyclonal Antibody, Unconjugated(bs-0828R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PAR1 Polyclonal Antibody, Unconjugated(bs-0828R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PAR-1 Polyclonal Antibody, Unconjugated(bs-0828R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat colitis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PAR-1 Polyclonal Antibody, Unconjugated(bs-0828R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining